Description
Description
Buy JWH-250/ JWH-073/ JWH-200/Online from Chemicals Pharm Store.
Summary
Are you looking to Buy JWH-250 Online /JWH-250 is a synthetic cannabinoid receptor agonist (SCRA) with a potency comparable to
that of delta-9-tetrahydrocannabinol (THC). JWH-250 has affinity for CB1 and CB2 receptors,
and shows three-fold selectivity for CB1-receptors.
JWH-250 is a psychoactive substance and has effects similar to those of THC. It has been
detected in herbal products marketed under a variety of names via the Internet and in
specialised shops. The quantity of JWH-250 among the different packages may vary
considerably.
No detailed data is available about the toxicity following the consumption of JWH-250 alone,
but four cases have been described following overdosing of the compound in combination
with other SCRA(s). In these cases, the serum level of JWH-250 was 0.10 ng/ml to 0.40
ng/ml, and the Poisoning Severity Score (PSS) was 1 to 2 (at 6 to 24 hours after
consumption). The most frequently observed symptoms in this study (those for JWH-250
were not separately specified) were tachycardia, hypertension, agitation, hallucinations, minor
elevation of blood glucose, hypokalemia and vomiting. Chest pain, seizures, myoclonia and
acute psychosis were also noted. No data are available about its dependence or abuse potential
of JWH-250. Considering its close pharmacological resemblance to THC, abuse of JWH-250 is likely to occur.
Buy JWH‐250 Online/Order JWH‐250 Wholesale /Retail Supplies Usage.
The best place to Buy JWH‐250 Online /36th ECDD (2014) Agenda item 4.11 JWH‐250
Page 8 of 20
1. Substance identification
A. International Nonproprietary Name (INN)
Not applicable.
B. Chemical Abstract Service (CAS) Registry Number
864445-43-2
C. Other Names
1-pentyl-3-(2-methoxyphenylacetyl)indole
1-(1-pentyl-1H-indol-3-yl)-2-(2-methoxyphenyl)ethanone
JWH-250
D. Trade Names
No information available.
E. Street Names
No information available.
F. Physical properties
In pure form, JWH-250 is a white powder.
G. WHO Review History
JWH-250 was not previously pre reviewed or critically reviewed. A direct
critical review is proposed based on information brought to WHO’s attention
that JWH-250 is clandestinely manufactured, of especially serious risk to
public health and society, and of no recognized therapeutic use by any party.
Preliminary data collected from literature and different countries indicated that
this substance may cause substantial harm and that it has no medical use.
2. Chemistry
A. Chemical Name
IUPAC Name: 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
CA Index Name: 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
High Quality JWH‐250 Online History .
36th ECDD (2014) Agenda item 4.11 JWH‐250
Page 9 of 20
B. Chemical Structure
Free base:
JWH-250
Molecular Formula: C22H25NO2
Molecular Weight: 335.2
Melting point: 82.6 °C
Boiling point: –
Fusion point: –
C. Stereoisomers
No stereoisomers exist.
D. Synthesis
JWH-250 was synthesized from 1-pentylindole and 2-
methoxyphenylacetylchloride by the Okauchi modification of the FriedelCrafts reaction.11
E. Chemical description
JWH-250 belongs to the category of the phenylacetylindoles and has structural
resemblance to other synthetic cannabinoids with a core indole structure, such
as the Schedule I substances JWH-018 and AM2201.
F. Chemical properties
No particular properties.
G. Chemical identification
NMR, FTIR and chromatographic methods with mass spectrometric detection
are available for the identification of JWH-250.5;21
3. Ease of convertibility into controlled substances
Based on its structure, it is not likely that JWH-250 can be converted into a controlled.
Buy JWH-250 Online to be used by research and forensic applications.
4. General pharmacology
4.1. Pharmacodynamics
JWH-250 belongs to the category of the synthetic cannabinoid receptor agonists
(SCRAs). SCRAs mimic the effects of delta-9-tetrahydrocannabinol (THC) by binding
to the CB1 and CB2 cannabinoid receptors in the brain and peripheral organs.
In the early 1990s, two cannabinoid receptors have been identified and named CB1 and
CB2. CB1 is primarily localised in the central nervous system (CNS), and CB2 in cells
mainly associated with the immune system, such as macrophages, lymph nodes,
spleen, and microglia cells.8;16;18;27 CB1 receptors are mainly found in the CNS-regions
involved in cognition, short-term memory, movement and motor function.3
Activation
of the CB1 receptor by THC or SCRAs modulates amongst others neurotransmitter
release in many inhibitory and excitatory synapses in the brain. These effects are
mediated through CB1 receptor coupled G-protein activation and finally result in
decreased activity of cAMP-dependent protein kinases.
For the cannabimimetics commonly found in herbal products, only few data in terms
of their potency are available.29 Wiley et al., (2013) reported receptor binding data
(CB1 and CB2) and in vivo potencies (spontaneous activity, anti-nociceptive effect,
rectal temperature, and ring immobility) of almost forty different JWH-compounds,
but JWH-250 was not included.31 Previously, the binding of JWH-250 was reported by
Huffman et al11 (cf. Table 1).
Using a molecular model of CB1 and CB2 cannabinoid receptors, the interaction i.e.
binding affinity of some 120 different SCRAs with both receptors was estimated
taking into account the transition from the inactive conformation of the receptor (R) to
the active (R*) one.24 Their calculations showed that JWH-250 was one of the nine
ligands with the highest affinity to the CB2-receptor. All those nine ligands contained
an ortho substituent on the aryl ring.
Table 1. Binding affinity of JWH-250 and THC (mean ± SEM) to CB1 and CB2
receptors.11
Compound Ki CB1
(nM)a
Ki CB2
(nM)a
Ratio Method Reference
JWH-250 11 ± 2 33 ± 2 0.33 a 11
THC 40.7 36.4 2
THC 15.3 25.1 17
THC 67 36 1.86 a 30
a CB1: displacement of CP-55,940 at rat brain membranes; CB2: cloned human
receptor preparation; ratio: Ki CB1 / Ki CB2
4.2. Routes of administration and dosage
As a substitute for cannabis, JWH-250 is usually smoked or sometimes ingested. The
dose required for the desired effect(s) is unknown.
