MDMA
Drug
Description3,4-Methylenedioxymethamphetamine, commonly known as ecstasy or molly, is a psychoactive drug primarily used for recreational purposes. The desired effects include altered sensations, increased energy, empathy, as well as pleasure. When taken by mouth, effects begin in 30 to 45 minutes and last 3 to 6 hours. Wikipedia
Formula: C₁₁H₁₅NO₂
Drug class: empathogen–entactogen; stimulant
Other names: 3,4-MDMA; Ecstasy (E, X, XTC); Molly; Mandy
Duration of action: 4–6 hours
Onset of action: 30–45 minutes (by mouth)
Metabolism: Liver, CYP450 extensively involved, including CYP2D6
Elimination half-life: (R)-MDMA: 5.8 ± 2.2 hours (variable); (S)-MDMA: 3.6 ± 0.9 hours (variable)
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are you looking to buy Online MDMA 3,4-Methylenedioxymethamphetamine Powder Crystals is an drug that acts as both a stimulant and psychedelic, producing an energizing effect, as well as distortions in time and perception and enhanced enjoyment from tactile experiences.1,2 Typically, MDMA (an acronym for its chemical name 3,4-methylenedioxymethamphetamine) is taken orally, usually in a tablet or capsule, and its effects last approximately 3 to 6 hours. The average reported dose is one to two tablets, with each tablet typically containing between 60 and 120 milligrams of MDMA.1 It is not uncommon for users to take a second dose of the drug as the effects of the first dose begin to fade.
MDMA Powder Crystals , 3,4-methylenedioxy-methamphetamine (MDMA) is a synthetic drug that alters mood and perception (awareness of surrounding objects and conditions). It is chemically similar to both stimulants and hallucinogens, producing feelings of increased energy, pleasure, emotional warmth, and distorted sensory and time perception.
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MDMA Powder Crystals was initially popular in the nightclub scene and at all-night dance parties (“raves”), but the drug now affects a broader range of people who more commonly call the drug Ecstasy or Molly.
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Best place to buy online MDMA Powder Crystals usually take it as a capsule or tablet, though some swallow it in liquid form or snort the powder. The popular nickname Molly (slang for “molecular”) often refers to the supposedly “pure” crystalline powder form of MDMA, usually sold in capsules. However, people who purchase powder or capsules sold as Molly often actually get other drugs such as synthetic cathinones (“bath salts”) instead (see “Added Risk of MDMA”).
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MDMA Powder Crystals in combination with other drugs such as alcohol or marijuana.
MDMA increases the activity of three brain chemicals:
Dopamine—causes a surge in euphoria and increased energy/activity
Norepinephrine—increases heart rate and blood pressure, which are particularly risky for people with heart and blood vessel problems
Serotonin—affects mood, appetite, sleep, and other functions. It also triggers hormones that affect sexual arousal and trust. The release of large amounts of serotonin likely causes the emotional closeness, elevated mood, and empathy felt by those who use MDMA
3,4-Methylenedioxymethamphetamine, commonly known as ecstasy, is a psychoactive drug used primarily as a recreational drug. The desired recreational effects include increased empathy, euphoria, and heightened sensations.
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Physical form
The most common salt is the hydrochloride (CAS-64057-70-1) which occurs as a white or off-white powder or as crystals soluble in water. The phosphate salt is also encountered. Illicit products are seen principally as white tablets with a characteristic impression (logo), less commonly as white powders or capsules. MDMA base is a colourless oil insoluble in water.
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Pharmacology
Whereas phenethylamines without ring substitution usually behave as stimulants, ring substitution (as in MDMA) leads to a modification in the pharmacological properties. Ingestion of MDMA causes euphoria, increased sensory awareness and mild central stimulation. It is less hallucinogenic than its lower homologue, methylenedioxyamphetamine (MDA). The terms empathogenic and entactogenic have been coined to describe the socialising effects of MDMA. Following ingestion, most of the dose of MDMA is excreted in the urine unchanged. Major metabolites are 3,4-methylenedioxyamphetamine (MDA) and O-demethylated compounds. Following a dose of 75 mg, the maximum plasma concentration of around 0.13 mg/L is reached within two hours. The plasma half-life is 6–7 hours. In animals, MDMA causes neurotoxicity, as evidenced by anatomical changes in axon structure and a persisting reduction in brain serotonin levels. The significance of these findings to human users is still unclear, although cognitive impairment is associated with MDMA use. Some of the pharmacodynamic and toxic effects of MDMA vary, depending on which enantiomer is used. However, almost all illicit MDMA exists as a racemic mixture. Fatalities following a dose of 300 mg have been noted, but toxicity depends on many factors, including individual susceptibility and the circumstances in which MDMA is used.
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Synthesis and precursors
There are four principal precursors which can be used in the manufacture of MDMA and related drugs: safrole, isosafrole, piperonal and 3,4-methylenedioxyphenyl-2-propanone (PMK). Safrole is the key starting material in so far as the other three can be synthesised from it. In the original Merck patent of 1914, safrole was reacted with hydrobromic acid to form bromosafrole, which was converted to MDMA using methylamine. Many illicit syntheses start with PMK and use either the Leuckart route or various reductive aminations including the aluminium foil method. All of these methods produce racemic MDMA. The four precursors noted above are listed in Table I of the United Nations 1988 Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances. The corresponding EU legislation is set out in Council Regulation (EEC) No 3677/90 (as later amended), which governs trade between the EU and third countries.
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Mode of use
MDMA in tablet form is almost always used orally (ingested), but the powdered form could also be snorted, inhaled or injected, although the latter route is rarely observed in the context of recreational ecstasy use.
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Other names
As some of the above names suggest, MDMA is a derivative of amphetamine and a member of the phenethylamine family. A number of homologous compounds with broadly similar effects, e.g. MDA (methylenedioxyamphetamine), MDEA (methylenedioxyethylamphetamine) and MBDB (N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine), have appeared, but have proved less popular. These and many other more distant relatives of MDMA have now been subsumed by the generic term ecstasy. Street terms for MDMA include Adam and XTC, but often reflect the imprinted logo, e.g. Mitsubishis, Love Doves and many others.
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Analysis
In common with many of its homologues, MDMA reacts with the Marquis field test to produce a dark blue/black coloration. The mass spectrum shows limited structure with a major ion at m/z = 58 and other ions at m/z = 135 and 77. Using gas chromatography, the limits of detection in plasma and urine are 1.6 μg/L and 47 μg/L respectively.
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Control status
MDMA, shown as (+/–)-N,α-dimethyl-3,4-(methylene-dioxy)phenethylamine, is listed in Schedule I of the United Nations 1971 Convention on Psychotropic Substances.
Additional information
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