Methylone (bk-MDMA)

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Methylone (bk-MDMA)

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Description
DescriptionMethylone is an empathogen and stimulant psychoactive drug. It is a member of the substituted amphetamine, substituted cathinone and substituted methylenedioxyphenethylamine classes. Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone.
Formula: C11H13NO3
Molar mass: 207.23 g/mol
Solubility in water: 357 kg/m³
ChemSpider ID: 21106350
ChemSpider: 21106350
PubChem CID: 27281606
People also search for: Mephedrone, MDMA,

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Description

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3,4-Methylenedioxymethcathinone (Methylone)
[“Bath salt,” bk-MDMA, MDMC, MDMCAT, “Explosion,” “Ease,” “Molly”]Methylone (bk-MDMA)Buy-Methylone-Bk-MDMA-Online Buy Meth(bk-MDMA)
December 2019
Introduction:
3,4-Methylenedioxymethcathinone (methylone) is a
designer drug of the phenethylamine class. Methylone is a
synthetic cathinone with substantial chemical, structural, and
pharmacological similarities to 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Animal studies indicate that
methylone has MDMA-like and (+)-amphetamine-like
behavioral effects. When combined with mephedrone, a
controlled schedule I substance, the combination is called
“bubbles.” Other names are given in the above title.
Licit Uses:
Methylone is not approved for medical use in the United
States.
Chemistry:
O
O
H
N
CH3
CH3
O
Methylone
Molecular Formula C11H13NO3
The core chemical structure of methylone identifies it as a
phenethylamine, and it is related in chemical structure to
MDMA differing only by an oxygen atom on the
phenethylamine side chain. Methylone is a solid at room
temperature. The Chemical Abstract Service (CAS) number
is 186028-79-5 and the Chemical Abstract index name is 1-
(1,3-benzodioxol-5-yl)-2-(methylamino)-1-propanone.
Pharmacology:
There are substantial pharmacological similarities
between methylone and MDMA. Methylone and MDMA,
similar to cocaine and methamphetamine, inhibit in vitro the
neuronal reuptake of the monoamines dopamine and
serotonin and increase concentrations of these monoamines
in the synaptic cleft. Similar to methamphetamine, methylone
and MDMA also increase, in vitro, the neuronal release of
these monoamines. An increase in monoamine
concentrations in the central nervous system is thought to be
involved in the pharmacological effects of these substances.
Methylone also resembles MDMA in drug discrimination
assays. Methylone fully substitutes (>80%) for MDMA in rats
trained to discriminate MDMA from saline. Methylone
(ED50=6.9 μmol/kg) was about half as potent as MDMA
(ED50=3.5 μmol/kg) in these studies. In rats trained to
discriminate (+)-amphetamine from saline, both methylone
(ED50=10.1 μmol/kg) and MDMA (ED50=7.5 μmol/kg)
completely (>80%) substituted for amphetamine with similar
potencies. Furthermore, methylone, similar to MDMA, does
not substitute for 4-methyl-2,5-dimethoxyamphetamine
(DOM), a schedule I hallucinogen, in rats trained to
discriminate DOM from saline.
Because of the structural and pharmacological similarities
between methylone and MDMA, the psychoactive effects, adverse
health risks, and signs of intoxication resulting from methylone
abuse are likely to be similar to those of MDMA. Several chat
rooms discussed pleasant and positive effects of methylone when
used for recreational purpose.

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User Population:
Methylone, like other synthetic cathinones, is a recreational
drug that emerged on the United States’ illicit drug market in
2009. It is perceived as being a ‘legal’ alternative to drugs of
abuse like MDMA, methamphetamine, and cocaine. Evidence
indicates that youths and young adults are the primary users of
synthetic cathinone substances which include methylone.
However, older adults also have been identified as users of these
substances.
High Quality methylone Online History .
Illicit Distribution:
Law enforcement has encountered methylone in the United
States as well as in several countries including the Netherlands,
United Kingdom, Japan, and Sweden. The National Forensic
Laboratory Information System (NFLIS) is a DEA database that
collects scientifically verified data on drug items and cases
submitted to and analyzed by federal, state and local forensic
laboratories in the United States. The System to Retrieve
Information from Drug Evidence (STRIDE)/STARLiMS provides
information on drug seizures reported to and analyzed by DEA
laboratories. Methylone was first identified by forensic
laboratories in 2009, with five drug reports. In 2011, there were
1,770 methylone reports with seizure reporting more than
doubling to 4,312 in 2012 and 10,944 in 2013. Although since
permanent scheduling became effective in 2013, laboratories
have identified 4,230 methylone reports in 2014 with a sharp
decrease to 369, 186, and 74 reports in 2015, 2016, and 2017,
respectively. For 2018, there were an estimated 38 drug reports.
Methylone has been found in products falsely marketed as
research chemicals, plant food, or bath salts. These products are
often sold at smoke shops, head shops, convenience stores, adult
book stores, and gas stations and can also be purchased on the
Internet. Methylone has been identified in law enforcement
seizures that were initially suspected to be MDMA and marketed
as “Molly.”
Control Status:
Methylone (including its salts, isomers, and salts of isomers)
is controlled in schedule I of the Controlled Substances Act.

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