DescriptionKetamine is a medication mainly used for starting and maintaining anesthesia. It induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include sedation in intensive care and treatment of pain and depression.
Other names: CI-581; CL-369; CM-52372-2
Melting point: 258 to 261 °C (496 to 502 °F)
Duration of action: : Intramuscular: 0.5–2 hours; Insufflation: 45–60 min; By mouth: 1–6+ hours;
Elimination half-life: : Ketamine: 2.5–3 hours; Norketamine: 12 hours;
Metabolism: Liver (N-demethylation):: Major: CYP3A4; Minor: CYP2B6, CYP2C9
Metabolites: Norketamine; Dehydronorketamine; Hydroxynorketamine; Conjugates;