Drink a beverage made with N.O.-Xplode powder 20 to 30 minutes before your workout and you'll have greater energy, endurance and mental focus, says the supplement's manufacturer, Bio-Engineered Supplements and Nutrition, or BSN. The U.S. Food and Drug Administration doesn't regulate the supplement, and all possible side effects may not have been identified, though it does contain some ingredients, such as creatine, that may benefit athletes. Avoid N.O.-Xplode if you are under age 18, take medication, have a medical condition or are pregnant, nursing or trying to get pregnant. Don't take more than recommended, and seek medical help if you experience any severe, persistent symptoms with use.