Hydrocodone
Hydrocodone, also known as dihydrocodeinone, is a semi-synthetic opioid synthesized from codeine, one of the opioid alkaloids found in the opium poppy.
Formula: C18H21NO3
Bioavailability: Oral: 70%, Rectal: 75%, Intravenous: 100%
Excretion: Renal
Onset of action: 10–20 minutes
Trade name: Zohydro ER, Hysingla ER
Duration of action: 4–8 hours
Metabolism: Hepatic: CYP3A4 (major; to norhydrocodone), CYP2D6 (minor; to hydromorphone)