Ketamine
Medication
Description
DescriptionKetamine is a medication mainly used for starting and maintaining anesthesia. It induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include sedation in intensive care and treatment of pain and depression.
Formula: C13H16ClNO
Other names: CI-581; CL-369; CM-52372-2
Melting point: 258 to 261 °C (496 to 502 °F)
Duration of action: : Intramuscular: 0.5–2 hours; Insufflation: 45–60 min; By mouth: 1–6+ hours;
Elimination half-life: : Ketamine: 2.5–3 hours; Norketamine: 12 hours;
Metabolism: Liver (N-demethylation):: Major: CYP3A4; Minor: CYP2B6, CYP2C9
Metabolites: Norketamine; Dehydronorketamine; Hydroxynorketamine; Conjugates;
Dilution: To prepare a dilute solution containing 1 mg of ketamine per mL, aseptically transfer 10 mL from a 50 mg per mL vial or 5 mL from a 100 mg per mL vial to 500 mL of Dextrose Injection, 5% or Sodium Chloride Injection, 0.9% (