Oxycodone Medication Description DescriptionOxycodone, sold under the brand name OxyContin among others, is an opioid medication used for treatment of moderate to severe pain. It is usually taken by mouth, and is available in immediate-release and controlled-release formulations. Onset of action: IR: 10–30 minutes; CR: 1 hour Duration of action: By mouth (IR): 3–6 hrs; By mouth (CR): 10–12 hrs Bioavailability: By mouth: 60–87% Excretion: Urine (83%) Solubility in water: HCl: 166 Elimination half-life: By mouth (IR): 2–3 hrs (same t1/2 for all ROAs); By mouth (CR): 4.5 hrs