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Buy 2-AI online, or 2-Aminoindane, is a structural analogue of amphetamine. It features the R3 terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane group, a bicyclic moeity containing a benzene ring fused to a pentane ring. 2-AI contains an amino group NH2 bound to R2 of the indane ring thus giving it the name 2-aminoindane. 2-AI is structurally analogous to NM-2-AI, lacking the N-substituted methyl group.The prototype aminoindane, 2-aminoindane (2-AI), is a cyclic analogue of amphetamine (see Figure 1). The 2-AI backbone structure can be modified to produce diverse chemical substances by substitution on the aromatic ring with a variety of functional groups, or the addition of a methylenedioxy bridge or N-alkylation; generating the following substances, respectively: 5-iodo-2-aminoindane (5-IAI, Figure 2c), 5,6-methylenedioxy-2-aminoindane (MDAI, Figure 2b) and N-methyl-2-aminoindane (NM-2AI, Figure 2d). Analogues of aminoindanes can be prepared using indanone, indene or after intramolecular cyclization of the acyl chloride derivative of 3-phenyl-2-propanoic acid.Buy 2-aminoindane online
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2-Aminoindane (2-AI) is a research chemical and drug with applications in neurologic disorders and psychotherapy. It is also a drug of abuse as a component of some bath salts, with potential for neurotoxicity and brain damage.Buy 2-aminoindane online
Therapeutic and illicit uses
Synthetic aminoindanes were originally developed in the context of anti-Parkinsonian drugs as a metabolite of rasagiline and as a tool to be used in psychotherapy. They are also commonly abused in the form of bath salts and widely substituted for ecstasy. Having a serotonergic mechanism, there is concern about risk for serotonin syndrome with their abuse. Deaths related to their toxic effects have been observed both in the laboratory in animal studies and in clinical encounters.2-AI is a rigid analogue of amphetamine and partially substitutes for it in rat discrimination tests.
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Aminoindans (AI) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids.1,2 2-AI is an aminoindane that serves as the starting point for the synthesis of psychoactive compounds, such as 5,6-methylenedioxy-2-aminoindane. 2-AI itself has modest analgesic and stimulatory properties.1 This product is intended for forensic applications.