DescriptionDesmetramadol, also known as O-desmethyltramadol, is an opioid analgesic and the main active metabolite of tramadol.
Molar mass: 249.349 g/mol
ChemSpider ID: 115703
ChEMBL Id: 1400
Elimination half-life: 6-8 hours
Other names: O-Desmethyltramadol; O-DSMT; Omnitram
Metabolism: CYP3A4 and CYP2B6
People also search for: Tramadol, 2-Fluorodeschloroketamine,
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Buy O-DSMT online /O-Desmethyltramadol (O-DSMT) is an opioid that has primarily been used indirectly due to it being a primary metabolite of the analgesic tramadol. Since the 2010s it has occasionally been used on its own as it has been sold through the grey market/research chemical market.
It has a longer duration than tramadol and more typical opioid-like effects, although it still impacts monoaminergic systems to an extent that might somewhat influence the effect profile.
O-Desmethyltramadol = O-DSMT; Desmetramadol; O-Demethyltramadol
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Molecular formula: C15H23NO2
Molecular weight: 249.354 g/mol
3 Experience Reports
8 Legality (As of January 2019)
Light: 15 – 30 mg
Common: 30 – 50 mg
Strong: 50 – 70+ mg
Some people report using doses in the hundreds of milligrams, including via more intense routes of administration like intravenous. Because too little information exists about higher doses and non-oral routes, it is best to stick with common oral doses.
It does seem true that some users fail to receive any notable effects at common doses and have to use over 100 mg to receive a positive experience. Despite this, common doses are still recommended as they will usually be sufficient in someone without a tolerance.
A few reports of rectal administration exist. When using via this route nausea might be reduced and it may be somewhat more potent vs. oral use, so dosing needs to be adjusted accordingly.
Oral use is usually preferred to intranasal.
Total: 5 – 7 hours
Onset: 00:30 – 01:00
O-DSMT has not been studied for medical uses, but it likely has efficacy in the same conditions as typical opioids like oxycodone and morphine. Also, based on research with tramadol, there’s some evidence indicating how much benefit people receive from tramadol is at least partly dependent on how much O-DSMT they produce (Kirchheiner, 2008 ; Stamer, 2007 ; Poulsen, 1996).
An animal study in rats did find O-DSMT had analgesic effects and those were blocked by a MOR antagonist (Valle, 2000). The effects were seen with the (R) enantiomer, as the (S) enantiomer produced no antinociception or respiratory depression at 2 to 10 mg/kg IV.
Physical euphoria/pleasant physical sensations
Reduced heart rate and blood pressure
Users who are seeking a classic opioid effect tend to prefer O-DSMT to tramadol, which makes sense when considering its pharmacology. Often it’s said to be pretty good in people who are relatively opioid naive and/or those who don’t have an opioid tolerance, whereas people who regularly use the strongest opioids may not find it very effective. It’s been compared favorably to codeine, tramadol, and kratom by a number of users.
It does not usually produce a substantial “rush” of euphoria and is therefore weaker in that respect than certain opioids, but it can reliably offer a relaxed, chill, and pleasantly sedated state. Relative to tramadol is can bring someone to a nodding-like state of relaxation and impaired consciousness, although too few reports of its effects exist to know if it as frequently produces a “nod” as other opioids.
Cognition will usually be somewhat impaired, leading to slowed thinking or brain fog. This is partly due to the sedating effect of O-DSMT not being counteracted by monoaminergic effects like it would be with tramadol and as a result, if someone is trying to receive mood enhancement and anxiolysis while still being functional, tramadol is sometimes a preferred drug.
Some mental stimulation is sometimes reported at light to common doses, especially early in the effect period, though this is less common than with tramadol.
Feelings of warmth and general coziness or fuzziness are often reported with common to strong doses and it can also be moderately numbing for sensations, though not nearly to the extent seen with dissociatives.
Itchiness is sometimes reported like with other opioids. It can be annoying, but in a fair portion of people the sensation is not very unpleasant and can even become pleasant upon itching. This may be combated by using an antihistamine with O-DSMT, though ones that affect the brain to a substantial degree, like DPH and hydroxyzine, will potentiate the sedative effects.
A strong sensation of labored breathing can be induced with strong doses. If you’re taking a common dose and notice a change in the sensation of respiration you most likely aren’t in any physical danger, but with an overdose the sensation of labored breathing is a sign of danger, which is why common doses are recommended.
250g, 30g, 50g